Crohn's Disease Nursing Care - Giving The Best
Nursing care is very important for any disease condition. The debilitating nature of can be quite disheartening. The condition of the patient deteriorates as the days go by. There is however very little cure that a patient can get from nursing care. The disease causes increased bowel movements during the day, causing dehydration to the person. The patient also has low levels of red blood cells leading to anemia in addition to fever and severe weight loss.
There have been very little findings about the causative factors for Crohn's disease. With very little understanding about the cause, the cure and the treatment options are also not many. If you suffer from a disease and have very little information on how to tackle it, it is best to learn to live with it and face it. You can provide good nursing care if you know how to tackle this disease.
Keep Yourself Informed
It is very important to give nursing care and love to a person suffering from the disease. More so, if there is nothing left to cure it. Appropriate care for includes understanding the reasons for the condition, options available and steps to be taken to prepare the body for the condition as well as to deal with the attack.
One of the symptoms of the is the inflammation of the gastrointestinal tract. This causes diarrhea, fatigue, fever and weight loss, skin rashes and mouth ulcers. As the main cause of the disease is unknown, you can find ways to treat and give some care to the symptoms that are exhibited. There are three main options for providing nursing care- medication, surgery and good nutrition.
Medication - Medicines for only have limiting power to alleviate pain, inflammation and manage the condition. There is unfortunately no medicine to cure the condition. You can consult your physician and find the medicine that is right for your symptoms. You need to work with your doctor and find out the best medication to relieve your pain and the symptoms.
Surgery
- This option is usually recommended for children who have been affected with a severe attack of the Crohn's disease. Surgery does not cure the condition but helps the children to deal with the condition better.
Good Nutrition - Good food and diet is an essential nursing care option in any disease condition. Diet plays a major role and helps to identify the foods responsible for aggravating the condition. You need to find out the foods which can flare up the condition...
- Oily or spicy foods are found to worsen the condition and you may also be sensitive to gluten or dairy products.
- Gluten free diet is found to reduce the symptoms of Crohn's disease. You can thus have natural foods like vegetables, meat and fish.
- Sugar is also found to flare up the condition. Sugar free diet is advised to keep the sugar levels at a consistent level.
- High fiber foods are found to irritate the intestinal lining and thus increase inflammation. You are thus prescribed a low residue diet. This diet may lack nutrients. The patient is thus advised to drink vegetable juice and take supplements for the nutrients.
- It is advisable to avoid alcohol, caffeine and foods high in sulfur.
- You should drink plenty of fluids as there is mineral loss in diarrhea.
- Also do exercise to keep the body fit.
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Symptoms Of Crohns Disease?
In my youth since the age of seven have always show symptoms of Crohn’s Disease. In fact I have been diagnosed no recently than 15 months ago and I turn Read more...
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perianal crohns disease activity index
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Musculoskeletal center wins $2.2 million for drug safety
The University of Alabama at Birmingham (UAB) Center for Education and Research on Therapeutics (CERTs) has won a $2.2 million federal grant to study the risks and benefits of a newer class of medicines called biologics. These are genetically engineered therapies that target the immune system of patients who have rheumatoid arthritis, Crohn's disease, psoriasis and other autoimmune disorders. (Source: Health News from Medical News Today)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Crohn's disease patients at risk of significant diagnostic radiation exposure
Recent findings published in the November issue of the journal Gut suggest that there are identifiable subsets of patients with Crohn's disease who are at risk of exposure to high levels of diagnostic radiation. Reuters Health Information (Source: Medscape Radiology Headlines)
Prometheus presents new clinical insights into diagnosis of crohn's disease in children from analysis of prometheus(r) ibd serology 7 test results
Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, announced new findings regarding the correlation between serologic markers and the diagnostic predictions of children with Crohn's disease following an analysis of PROMETHEUS(R) IBD Serology 7 test results. (Source: Crohn's News From Medical News Today)
Crohn's disease patients at risk of significant diagnostic radiation exposure
NEW YORK (Reuters Health), Nov 18 - Recent findings published in the November issue of the journal Gut suggest that there are identifiable subsets of patients with Crohn's disease who are at risk of exposure to high levels of diagnostic radiation. (Source: AuntMinnie.com Headlines)
Crohn's disease surgeries make steady advances
(New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College) Thousands of Americans suffering from the chronic inflammatory bowel condition known as Crohn's disease are leading longer, healthier lives due to innovative new surgeries, according to experts at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. (Source: EurekAlert! - Cancer)
Musculoskeletal center wins $2.2 million for drug safety
(University of Alabama at Birmingham) The UAB Center for Education and Research on Therapeutics has won a $2.2 million federal grant to study the risks and benefits of a class of drugs called "biologics." These are agents genetically engineered to target the immune system of patients with rheumatoid arthritis, Crohn's disease, psoriasis and other autoimmune disorders. The grant will allow the UAB center to pinpoint which biologics have safety concerns and which work best for specific groups of patients. (Source: EurekAlert! - Biology)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
The world in medicine: gut bacteria and crohn disease
(Source: JAMA)
Escherichia coli type 1 pili trigger late il-8 production by neutrophil-like differentiated plb-985 cells through a src family kinase- and mapk-dependent mechanism.
Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase- and MAPK-dependent mechanism.
J Leukoc Biol. 2008 Nov 17;
Authors: Semiramoth N, Gleizes A, Turbica I, Sandre C, Gorges R, Kansau I, Servin A, Chollet-Martin S
The innate immune response to enteropathogenic bacteria includes chemokine-induced polymorphonuclear neutrophil (PMN) migration across mucosal epithelia leading to bacterial clearance and resolution of infection. Among these bacteria, diffusely adherent Escherichia coli expressing Afa/Dr fimbriae (Afa/Dr DAEC), causing childhood diarrhea, can promote IL-8-dependent PMN transmigration across cultured intestinal epithelial cell monolayers via MAPK pathway activation. However, interactions b...
Crohn's disease researchers in plea for study volunteers
PATIENTS with Crohn's disease are being invited to take part in pioneering research that may find the first preventative medicine for their condition. (Source: Scotsman.com News - Health)
Crohn's disease in an african-american population.
Page: 389DOI: 10.1097/MAJ.0b013e31816a5c06Authors: JACKSON, JAMES F. III MD; DHERE, TANVI MD; REPAKA, APARNA MD; SHAUKAT, AASMA MD, MPH; SITARAMAN, SHANTHI MD, PhD (Source: The American Journal of the Medical Sciences)
Predictive value of serologic markers in a population-based norwegian cohort with inflammatory bowel disease
Conclusions: The prevalence of ASCA in CD and pANCA in UC appears markedly lower than in referral-based populations. Even with the low prevalence, our study gives further support to the role of ASCA and pANCA as markers for distinct phenotype and outcome of disease.(Inflamm Bowel Dis 2008) (Source: Inflammatory Bowel Diseases)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Adalimumab may reduce health-care costs for crohn's disease patients
Additional study shows further research needed on 5-ASA's chemopreventative role in ulcerative colitis Inflammatory bowel disease (IBD) is a term that refers to both ulcerative colitis (UC) and Crohn's disease (CD). IBD occurs most frequently in people in their late teens and twenties. There have been cases in children as young as two years old and in older adults in their seventies and eighties; men and women have an equal chance of getting the disease. (Source: Crohn's News From Medical News Today)
A faster test for the food protein that triggers celiac disease - analytical chemistry journal
Researchers in Spain and the United Kingdom are reporting development of a faster test for identifying the food protein that triggers celiac disease, a difficult-to-diagnose digestive disease involving the inability to digest protein called gluten that occurs in wheat, oats, rye, and barley. The finding could help millions of people avoid diarrhea, bloating, and other symptoms that occur when they unknowingly eat foods containing gluten. (Source: Crohn's News From Medical News Today)
Snp-guided microrna maps (mirmaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways.
We report the results of a disease phenocode analysis interrogating the relationships between structural features and gene expression patterns of disease-linked SNPs, microRNAs and mRNAs of protein-coding genes in association to phenotypes of 16 major human disorders, which was enabled by multiple independent studies of up to 451,012 combined samples including 194,258 disease cases and 256,754 controls. SNP sequence homology-guided microRNA maps (MirMaps) identify consensus components of a disease phenocode consisting of 81 SNPs and 17 microRNAs. microRNAs of the consensus set are associated with at least 4 common human diseases (range 4 to 7 diseases) and manifest sequence homology/complementarity to at least 4 distinct disease-linked SNPs (range 4 to 14 SNPs). Nearly all microRNAs (15 of...
Adalimumab may reduce health-care costs for crohn's disease patients
Inflammatory bowel disease (IBD) is a term that refers to both ulcerative colitis (UC) and Crohn's disease (CD). IBD occurs most frequently in people in their late teens and twenties. There have been cases in children as young as two years old and in older adults in their seventies and eighties; men and women have an equal chance of getting the disease. (Source: Huliq Health News)
Azathioprine is superior to budesonide in achieving and maintaining mucosal healing and histologic remission in steroid-dependent crohn's disease
Conclusions: In patients with steroid-dependent inflammatory Crohn's ileocolitis or proximal colitis who achieve clinical remission with conventional steroids, a 1-year treatment with AZA was superior to BUD in achieving and maintaining mucosal healing and histologic remission.(Inflamm Bowel Dis 2008) (Source: Inflammatory Bowel Diseases)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Iron in water supply linked to inflammatory bowel diseases
The risk of developing ulcerative colitis and Crohn's disease is associated with elevated iron levels in drinking water, according to a study in Norway. Reuters Health Information (Source: Medscape PublicHealth Headlines)
Philips' intelligent pill targets drug development and treatment for digestive tract diseases
At this week's opening of the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition (Atlanta, USA, November 16-20, 2008) Philips Research will announce its new intelligent pill technology "iPill", targeted at assisting drug development and enabling new therapies for debilitating and life-threatening digestive tract disorders such as Crohn's disease, colitis and colon cancer. (Source: Crohn's News From Medical News Today)
Fda approves deadly enbrel drug for children
(NaturalNews) An FDA advisory panel has recommended the approval of Amgen's immune-suppressing drug Enbrel (generic name etanercept) for the treatment of psoriasis in children, in spite of ongoing concerns that the drug may have lethal side effects.The recommendation came only two days after an independent panel recommended that the FDA strengthen Enbrel's label with warnings about potentially fatal side effects such as anemia, seizures, serious infections, cancer or neurological problems. It also comes as the FDA is investigating whether the entire drug family of which Enbrel is a part increases the risk of cancer in children, particularly lymphoma.The FDA is investigating 30 reports of cancer in children and young adults who have been treated with drugs in the family, known as tumor necr...
Adalimumab may reduce health-care costs for crohn's disease patients
(American Gastroenterological Association) Inflammatory bowel disease is a term that refers to both ulcerative colitis and Crohn's disease. IBD occurs most frequently in people in their late teens and twenties. There have been cases in children as young as two years old and in older adults in their seventies and eighties; men and women have an equal chance of getting the disease. (Source: EurekAlert! - Medicine and Health)
Withdrawal of immunosuppression in crohn's disease treated with scheduled infliximab maintenance.
Withdrawal of Immunosuppression in Crohn's Disease Treated With Scheduled Infliximab Maintenance.
Gastroenterology. 2008 Nov 12;
Authors: Francis G, Duggan A
PMID: 19013168 [PubMed - as supplied by publisher] (Source: Gastroenterology)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
The direct and indirect cost burden of crohn's disease and ulcerative colitis.
Page: 1261DOI: 10.1097/JOM.0b013e318181b8caAuthors: Gibson, Teresa B. PhD; Ng, Eliza MD; Ozminkowski, Ronald J. PhD; Wang, Shaohung PhD; Burton, Wayne N. MD; Goetzel, Ron Z. PhD; Maclean, Ross MD, MBA (Source: Journal of Occupational and Environmental Medicine)
Guidelines for the management of inflammatory bowel disease in children in the united kingdom
These clinical guidelines provide an evidence and consensus based document describing good clinical practice for the investigation and treatment of IBD (ulcerative colitis and crohn's disease) in children under the age of 18 years, which will promote more consistent clinical care. (Source: Gastroenterology and Liver Diseases Specialist Library - Inflammatory bowel disease)
Abbott's humira® (adalimumab) data shows fistula healing for up to three years in patients with moderate to severe crohn's disease
New data showed that Abbott's (NYSE: ABT) HUMIRA® (adalimumab) provided long-term treatment of fistulas, with more than half of patients with moderate to severe Crohn's disease experiencing fistula healing at three years, according to clinical research presented today at the United European Gastroenterology Week (UEGW) congress in Vienna. (Source: Health News from Medical News Today)
Helminth antigen-based strategy to ameliorate inflammation in an experimental model of colitis
Inflammatory bowel disease (IBD) is the most common and serious chronic inflammatory condition of the gut. Among the distinct T helper (Th) cell subsets, a Th1 type response is associated predominantly with Crohn's disease (CD) while helminth infections generate a strong Th2 type response. IBD is most prevalent in developed countries but rare in countries where infections with helminths are common. Thus, it has been hypothesized that infection with helminth infection influence the development of CD and recent clinical and experimental studies suggest strongly a beneficial role of helminth infection in IBD. In the present study we examined the effects of rectal submucosal administration of helminth antigens on subsequent experimental colitis. Mice were treated with Trichinella spiralis anti...
Ask the experts: do sex-related differences affect clinical course and outcome in crohn's disease?
Sunanda V. Kane, MD, MSPH, FACG, discusses gender-related issues that may have an impact on clinical course and/or management in Crohn's disease.
Medscape Gastroenterology (Source: Medscape FamilyMedicine Headlines)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Concomitant carcinoid tumor and papillary urothelial neoplasm of low malignant potential in a patient with crohn's disease: a case report.
Page: 1231DOI: 10.1097/MEG.0b013e328302f484Authors: Owczarek, Danuta a; Cibor, Dorota a; Szczepanski, Wojciech b; Kosowski, Bogdan c; Mach, Tomasz a (Source: European Journal of Gastroenterology & Hepatology)
Fight back against inflammatory bowel disease.
Is it ulcerative colitis or Crohn's disease? These gut-wrenching disorders have much in common, but they also differ significantly. Make sure you can sort them out so you're prepared to intervene appropriately.Page: 34DOI: 10.1097/01.NURSE.0000341077.75953.74Authors: Day, Michael W. RN, CCRN, MSN (Source: Nursing)
Intestinal macrophage/epithelial cell-derived ccl11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis.
In this study we demonstrate, by gene array and quantitative PCR, elevated levels of eotaxin-1 mRNA in the rectosigmoid colon of pediatric UC patients. We show that elevated levels of eotaxin-1 mRNA positively correlated with rectosigmoid eosinophil numbers. Further, colonic eosinophils appeared to be degranulating, and the levels positively correlated with disease severity. Using the dextran sodium sulfate (DSS)-induced intestinal epithelial injury model, we show that DSS treatment of mice strongly induced colonic eotaxin-1 and eotaxin-2 expression and eosinophil levels. Analysis of eosinophil-deficient mice defined an effector role for eosinophils in disease pathology. DSS treatment of eotaxin-2(-/-) and eotaxin-1/2(-/-) mice demonstrated that eosinophil recruitment was dependent on eota...
Appendiceal mucinous cystadenoma is a neoplastic complication of ibd: case-control study of primary appendiceal neoplasms
Conclusions: IBD with synchronous colorectal dysplasia or cancer is a risk factor for development of appendiceal cystadenomas, implicating this tumor as a neoplastic complication of IBD. IBD does not predispose to the development of appendiceal carcinoids.(Inflamm Bowel Dis 2008) (Source: Inflammatory Bowel Diseases)
Meta-analysis - enteral nutrition in active crohn's disease in children
A structured abstract written by CRD reviewers. (Source: Gastroenterology and Liver Diseases Specialist Library - Common clinical problems)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Gallstone ileus following endoscopic retrograde cholangiopancreatography and sphincterotomy: a case report
Conclusion:
A gallstone may enter the gastrointestinal tract following endoscopic retrograde cholangiopancreatography and sphincterotomy and impact proximal to an anastomotic stricture as demonstrated here. The radiographic image of small bowel obstruction plus air in the biliary tree is a classic diagnostic finding. After stone extraction, the entire small bowel and colon should be digitally examined for further stones. (Source: Journal of Medical Case Reports)
Previously unknown immune cell may help those with crohn's and colitis
The tonsils and lymphoid tissues in the intestinal tract that help protect the body from external pathogens are the home base of a rare newly identified immune cell. Researchers indicate that the immune cells could have a therapeutic role in inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. (Source: ScienceDaily Headlines)
Limited effects of dietary curcumin on th-1 driven colitis in il-10 deficient mice suggest an il-10-dependent mechanism of protection
In conclusion, curcumin demonstrates limited effectiveness on Th-1 mediated colitis in IL-10–/– mice, with moderately improved colonic morphology, but with no significant effect on pathogenic T cell responses and in situ NF-B activity. In vitro studies suggest that the protective effects of curcumin are IL-10 dependent. (Source: AJP: Gastrointestinal and Liver Physiology)
Previously unknown immune cell may help those with crohn's and colitis
The tonsils and lymphoid tissues in the intestinal tract that help protect the body from external pathogens are the home base of a rare immune cell newly identified by researchers at Washington University School of Medicine in St. Louis. (Source: Huliq Health News)
Tumor necrosis factor antagonists for crohn's disease: effective, but safe?
Page: 78DOI: 10.1097/EBG.0b013e31818d40ffAuthors: Swoger, Jason M. MD, MPH; Kane, Sunanda V. MD, MSPH (Source: Evidence-Based Gastroenterology)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Newly discovered immune cell may help those with crohn's and colitis
The tonsils and lymphoid tissues in the intestinal tract that help protect the body from external pathogens are the home base of a rare immune cell newly identified by researchers at Washington University School of Medicine in St. Louis. The researchers indicate that the immune cells could have a therapeutic role in inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. (Source: Immune System / Vaccines News From Medical News Today)
Patients with inflammatory bowel disease may have a transforming growth factor-β-, interleukin (il)-2- or il-10-deficient state induced by intrinsic neutralizing antibodies
This study shows that about one-third of IBD patients may have a relative deficiency of TGF-[beta], IL-2 or IL-10 due to an increase in neutralizing antibodies in their sera. (Source: Clinical and Experimental Immunology)
Clinical course of late-onset crohn's disease
No abstract. (Source: Inflammatory Bowel Diseases)
Autophagy gene atg16l1 but not irgm is associated with crohn's disease in canadian children
Background: Recent genome-wide studies have implicated the autophagy genes ATG16L1 and IRGM in the pathogenesis of Crohn's disease (CD). We investigated whether these genes were associated with CD in Canadian children.Methods: A case-control study was carried out at 2 pediatric gastroenterology clinics in Canada. Confirmed cases of CD (Source: Inflammatory Bowel Diseases)
Previously unknown immune cell may help those with crohn's and colitis
(Washington University School of Medicine) The tonsils and lymphoid tissues in the intestinal tract that help protect the body from external pathogens are the home base of a rare immune cell newly identified by researchers at Washington University School of Medicine in St. Louis. The researchers indicate that the immune cells could have a therapeutic role in inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. (Source: EurekAlert! - Infectious and Emerging Diseases)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Pharmacokinetics, safety, and tolerability of teduglutide, a glucagon-like peptide-2 (glp-2) analog, following multiple ascending subcutaneous administrations in healthy subjects.
Pharmacokinetics, Safety, and Tolerability of Teduglutide, a Glucagon-Like Peptide-2 (GLP-2) Analog, Following Multiple Ascending Subcutaneous Administrations in Healthy Subjects.
J Clin Pharmacol. 2008 Nov;48(11):1289-99
Authors: Marier JF, Beliveau M, Mouksassi MS, Shaw P, Cyran J, Kesavan J, Wallens J, Zahir H, Wells D, Caminis J
Teduglutide, a glucagon-like peptide-2 (GLP-2) analog, is currently being evaluated for the treatment of short-bowel syndrome, Crohn's disease, and other gastrointestinal disorders. The pharmacokinetics, safety, and tolerability of teduglutide in healthy subjects (N = 64) were assessed following daily subcutaneous administrations for 8 days in a double-blinded, randomized, placebo-controlled, ascending-dose study. Teduglutide treatments were adminis...
The suppressive effect of triptolide on chronic colitis and tnf-alpha/tnfr2 signal pathway in interleukin-10 deficient mice.
In this study, we evaluated its possible therapeutic effects on colitis in interleukin-10 deficient mice, a murine model of Crohn's disease. Triptolide was administered to IL-10(-/-) mice intraperitoneally every other day for 8 weeks. The severity of colitis in IL-10(-/-) mice was obviously reduced after triptolide treatment, with a reduction in the numbers of CD4+ T cells and macrophages in lamina propria. Triptolide also significantly decreased the production of TNF-alpha and IFN-gamma in colon. Furthermore, triptolide suppressed TNFR2 expression and NF-kappaB activation in colon of IL-10(-/-) mice. These data suggested that triptolide could ameliorate Th1-mediated chronic colitis and disordered immune state in IL-10(-/-) mice. A possible mechanism could be inhibiting TNF-alpha/TNFR2 sig...
Attenuation of colitis injury in rats using garcinia cambogia extract
In this study, the antiinflammatory activity of a garcinia extract was assessed in TNBS-induced colitis rats. The results obtained revealed that garcinia administration to colitic rats significantly improved the macroscopic damage and caused substantial reductions in increases in MPO activity, COX-2 and iNOS expression. In addition, garcinia extract treatment was able to reduce PGE2 and IL-1[bgr] colonic levels. These antiinflammatory actions could be related to a reduction in DNA damage in isolated colonocytes, observed with the comet assay. Finally, garcinia extract caused neither mortality nor toxicity signals after oral administration. As such, the antiinflammatory effects provided by the Garcinia cambogia extract result in an improvement of several parameters analysed in experimental ...
Il-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease.
IL-23 and Autoimmunity: New Insights into the Pathogenesis of Inflammatory Bowel Disease.
Annu Rev Med. 2008 Oct 31;
Authors: Abraham C, Cho JH
The intestinal immune system has the challenge of maintaining both a state of tolerance toward intestinal antigens and the ability to combat pathogens. This balance is partially achieved by reciprocal regulation of proinflammatory, effector CD4(+) T cells, and tolerizing, suppressive Treg subsets. Inflammatory bowel disease (IBD) comprises Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have linked CD to a number of IL-23 pathway genes, notably IL23R (interleukin 23 receptor). Similar associations in IL-23 pathway genes have been observed in UC. IL23R is a key differentiation feature of CD4(+) Th17 cell...
Acg 2008: inflammatory bowel disease
Uma Mahadevan-Velayos, MD, and Bret Lashner, MD, provide in-depth clinical updates on the latest issues in Crohn's disease and ulcerative colitis, based on selected sessions at ACG 2008. Medscape Gastroenterology (Source: Medscape FamilyMedicine Headlines)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Pancreatic autoantibodies are associated with reactivity to microbial antibodies, penetrating disease behavior, perianal disease, and extraintestinal manifestations, but not with nod2/card15 or tlr4 genotype in a hungarian ibd cohort
Conclusions: PAB autoantibodies in combination with ASCA or anti-glycan antibodies increase the sensitivity for detecting CD, especially isolated colonic CD. Antibody response to PAB was associated with complicated disease phenotype and extraintestinal manifestations in this Eastern European IBD cohort.(Inflamm Bowel Dis 2008) (Source: Inflammatory Bowel Diseases)
Il1β- and lps-induced serotonin secretion is increased in ec cells derived from crohn's disease
We examined whether interleukin (IL)1[beta] and Escherichia coli lipopolysaccharide (LPS) induced EC cell 5HT release through Toll-like/IL-1 (TIL) receptor activation, nuclear factor kappa B (NF[kappa]B) and mitogen-activated protein kinase (MAPK) phosphorylation and evaluated whether somatostatin could inhibit this phenomenon. Pure (>98%) human intestinal EC cells were isolated by fluorescent activated cell sorting from preparations of normal (n = 5) and Crohn's colitis (n = 6) mucosa. 5HT release was measured (ELISA), and NF[kappa]B and ERK phosphorylation quantitated (ELISA) in response to IL1[beta] and LPS. 5HT secretion was increased by both E. coli LPS (EC50 = 5 ng mL[minus]1) and IL1[beta] (EC50 = 0.05 pmol L[minus]1) >2-fold (P < 0.05) in Crohn's EC cells compared with normal EC ce...
Imaging for crohn disease: use of 3-t mri in a paediatric setting
This study was carried out to review our experience with 3-T MRI in the assessment of Crohn disease in a paediatric population. Twenty-four patients with biopsy proven Crohn disease identified on the radiology information system underwent abdominal MRI, with or without pelvic MRI. Twenty-eight studies were carried out on a 3-T scanner at a tertiary paediatric hospital. Eight of 24 of these (30%) had a gastrointestinal barium study, 2 of 24 (8%) a CT and 9 of 24 (38%) an abdominal ultrasound. The different MRI sequences were rated for observation of the bowel wall and abnormalities (0[ndash]5). The findings were correlated to relevant findings on endoscopy, examination under anaesthesia (EUA) and where available surgery, barium studies, CT and ultrasound. In this study, the colon was involv...
Transcutaneous posterior tibial nerve stimulation for fecal incontinence in inflammatory bowel disease patients: a therapeutic option?
Conclusion: These preliminary results are encouraging, although further studies are necessary. Posterior tibial nerve electrical stimulation may represent a new therapeutic option to treat the difficult problem of fecal incontinence in patients with IBD.(Inflamm Bowel Dis 2008) (Source: Inflammatory Bowel Diseases)
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