Crohns and Diet

I’ve been affected by Crohn’s my entire life but as of right now I’m in remission. And I’ll ill tell you how I did it. I know we’ve all heard it has been proven that there is no link between Crohn’s and diet I am living proof that this is a lie! I love life and spend time with friends and family that I never thought I’d have. I’m loving life and you could be too How I beat Crohn’s and Colitis naturally is what showed me how. I remember being at my wits end relying on the medical profession to make me “better”with no sign of change. When I found How I beat Crohn’s and Colitis naturally it gave me so much information that I was hidden from by today’s food and medical industries. If you could get the information to create a diet for yourself that isn’t only as tasty as can be, but can and will help you control the disease that your doctors tell you visit after visit “there doing all they possibly can for you” .as you sit there helpless and sick with no change at all besides a lighter wallet and the sensation of feeling worse then you ever have before being on the meds when u miss a single dose of them. I’m telling you this as a real Crohn’s victim. And a real man with a new sense of life! Thanks to the nutritional decisions I made from the information brought to light by  
Scheduled Maintenance Therapy with Infliximab Improves the Prognosis of Crohn's Disease: A Single Center Prospective Cohort Study in Japan.
Authors: Takahashi S, Takagi S, Shiga H, Umemura K, Endo K, Kakuta Y, Takahashi S, Kinouchi Y, Shimosegawa T The main goal of Crohn's disease (CD) treatment at present is to induce and maintain remission for as long as possible, and several approaches have been used as induction and maintenance therapies. There are no reports that have compared the effects on mid- and long-term prognosis among the induction and maintenance therapies, especially between infliximab, a chimeric antibody to tumor necrosis factor-alpha, and nutritional therapies. A total of 262 CD patients with induced remission were enrolled in the cohort study. Patients who failed to achieve remission, and patients who were lost to follow-up within 12 months were excluded. Induction therapies for CD included total element...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Crohn's disease: Why I won't let it control my life
MUSICIAL Rick Parfitt Jnr, 35, the son of Status Quo's legendary rocker, talks about the illness he has battled since childhood and why he has now helped set up his own charity to try to find a cure. (Source: Daily Express - Health)
Colonoscopy in Hong Kong Chinese children.
CONCLUSION: Colonoscopy is a safe procedure in our Chinese children. The increasing diagnosis of IBD in recent decades may reflect a rising incidence of the disease in our children. PMID: 20205284 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Nod proteins link bacterial sensing and autophagy.
Authors: Travassos LH, Carneiro LA, Girardin S, Philpott DJ Autophagy is one of the main cellular degradation systems in eukaryotes, responsible for the elimination of long-lived proteins and damaged organelles. Besides its well-documented role as a housekeeping mechanism, autophagy has recently caught the attention of groups working in the fields of microbiology and immunology, especially those working in innate immunity. In particular, the highly specific segregation and degradation of intracellular bacteria by the autophagic machinery was a matter of great interest. However, it was still unclear how the autophagy machinery could target intracellular bacteria with such specificity. We have recently analyzed the role of the intracellular peptidoglycan (PG) receptors Nod1 and Nod2 as a...
Crohn's disease - infliximab (review) and adalimumab: final appraisal determination
(Source: NHS Evidence - Gastroenterology and liver diseases - News)
Clinical Outcome of Newly Diagnosed Crohn's Disease: A Comparative, Retrospective Study Before and After Infliximab Availability
What effect did the introduction of the anti-TNF antibody infliximab have on the course of early Crohn's disease? Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Long-term outcome of endoscopic dilatation in patients with Crohn's disease is not affected by disease activity or medical therapy
Conclusion This largest series ever reported confirms that long term efficacy of endoscopic dilatation of Crohn's disease outweighs the complication risk. Neither active disease at the time of dilatation nor medical therapy afterwards predict recurrent dilatation or surgery. (Source: Gut)
Management of Crohn's disease
(Source: Gut)
Long-term value of endoscopic dilatation for Crohn's strictures
(Source: Gut)
Gene Sequencing Yields Picture of Human Gut
Title: Gene Sequencing Yields Picture of Human GutCategory: Health NewsCreated: 3/4/2010 2:10:00 PMLast Editorial Review: 3/5/2010 (Source: MedicineNet Crohn's Disease General)
Salmonella Scare Prompts Wide Product Recall
Title: Salmonella Scare Prompts Wide Product RecallCategory: Health NewsCreated: 3/4/2010 8:10:00 PMLast Editorial Review: 3/5/2010 (Source: MedicineNet Crohn's Disease General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Health Tip: What's Lactose Intolerance?
Title: Health Tip: What's Lactose Intolerance?Category: Health NewsCreated: 3/5/2010 10:10:00 AMLast Editorial Review: 3/5/2010 (Source: MedicineNet Crohn's Disease General)
NICE Recommends Infliximab And Adalimumab For The Treatment Of Severe, Active Crohn's Disease
In final draft guidance published today (4 March) NICE has recommended infliximab and adalimumab as treatment options for people with severe, active Crohn's disease whose condition has not responded to conventional therapy, or who are intolerant of or have contraindications to conventional therapy. Crohn's disease is a chronic inflammatory condition of unknown cause affecting the gastrointestinal tract (gut). It is estimated that around 60,000 people in the UK have the disease, with approximately 3,000 (5%) having the most severe forms of the condition... (Source: Health News from Medical News Today)
NICE Recommends Infliximab And Adalimumab For The Treatment Of Severe, Active Crohn's Disease
In final draft guidance published today (4 March) NICE has recommended infliximab and adalimumab as treatment options for people with severe, active Crohn's disease whose condition has not responded to conventional therapy, or who are intolerant of or have contraindications to conventional therapy... (Source: Crohn's News From Medical News Today)
NICE sets out Crohn's drug choices
People with chronic Crohn's disease, especially those who have not responded to conventional therapy, should be treated with infliximab or adalimumab, the National Institute for Clinical Excellence (NICE) has recommended. (Source: Pharmacy Europe)
NICE recommends infliximab and adalimumab for Crohn's disease treatment
In final draft guidance published today (4 March) NICE has recommended infliximab and adalimumab as treatment options for people with severe, active Crohn?s disease whose condition has not responded to conventional therapy, or who are intolerant of or have contraindications to conventional therapy. (Source: Nursing Times Breaking News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
A1c Test Identifies Diabetes, Heart Risk
Title: A1c Test Identifies Diabetes, Heart RiskCategory: Health NewsCreated: 3/4/2010 11:15:00 AMLast Editorial Review: 3/4/2010 11:15:54 AM (Source: MedicineNet Crohn's Disease General)
Food-borne Illnesses in U.S. Cost $152B Annually
Title: Food-borne Illnesses in U.S. Cost $152B AnnuallyCategory: Health NewsCreated: 3/3/2010 10:10:00 AMLast Editorial Review: 3/4/2010 (Source: MedicineNet Crohn's Disease General)
STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility
Authors: M C C&#233;nit, A Alcina, A M&#225;rquez, J L Mendoza, M D&#237;az-Rubio, V de las Heras, G Izquierdo, R Arroyo, O Fern&#225;ndez, E G de la Concha, F Matesanz & E Urcelay (Source: Genes and Immunity)
NICE issues Final Appraisal Determination on infliximab and adalimumab for Crohn's disease
Source: NICE Area: News NICE has prepared a Final Appraisal Determination on infliximab and adalimumab for Crohn's disease which contained the following preliminary recommendations: &nbsp; .&nbsp;Infliximab and adalimumab, within their licensed indications, are recommended as treatment options for adults with severe active Crohn's disease whose disease has not responded to conventional therapy (including immunosuppressive and/or corticosteroid treatments), or who are intolerant of or have contraindications to conventional therapy. Infliximab or adalimumab should be given as a planned course of treatment until treatment failure (including the need for surgery), or until 12 months after the start of treatment, whichever is shorter. People should then have their disease reassessed to det...
Smoking, Use of Moist Snuff and Risk of Chronic Inflammatory Diseases.
CONCLUSION: Smokeless tobacco does not increase the risk of chronic inflammatory diseases, suggesting that inhaled non-nicotinic components of cigarette smoke are more important than nicotine itself in the aetiology of these diseases. PMID: 20203245 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Does Vitamin D Deficiency Cause Symptoms?
Title: Does Vitamin D Deficiency Cause Symptoms?Category: Doctor's ViewsCreated: 3/3/2010 1:48:00 PMLast Editorial Review: 3/3/2010 1:48:43 PM (Source: MedicineNet Crohn's Disease General)
For Some on Dialysis, Anemia Drugs Pose Risks
Title: For Some on Dialysis, Anemia Drugs Pose RisksCategory: Health NewsCreated: 3/2/2010 4:10:00 PMLast Editorial Review: 3/3/2010 (Source: MedicineNet Crohn's Disease General)
Hepatopancreatobiliary manifestations and complications associated with inflammatory bowel disease
Abstract: Diseases involving the hepatopancreatobiliary (HPB) system are frequently encountered in patients with inflammatory bowel disease (IBD). Hepatobiliary manifestations constitute some of the most common extraintestinal manifestations of IBD. They appear to occur with similar frequency in patients with Crohn's disease or ulcerative colitis. HPB manifestations may occur in following settings: 1) disease possibly associated with a shared pathogenetic mechanism with IBD including primary sclerosing cholangitis (PSC), small-duct PSC/pericholangitis and PSC/autoimmune hepatitis overlap, acute and chronic pancreatitis related to IBD; 2) diseases which parallel structural and physiological changes seen with IBD, including cholelithiasis, portal vein thrombosis, and hepatic abscess; and 3) ...
Genetics of inflammasome-associated disorders: A lesson in the guiding principals of inflammasome function.
Authors: Rodrigue-Gervais IG, Saleh M Human genetics research has had a great impact on the genesis of the inflammasome field and the treatment of certain inflammasomopathies. The identification of mutations causing rare autoinflammatory syndromes, reproductive wastage disorders and of single nucleotide polymorphisms influencing susceptibility to complex diseases such as vitiligo, sepsis, and Crohn's disease has not only led to the characterization of novel proteins involved in NOD-like receptor-coupled inflammatory signaling pathways but also to greater insights into pathogenic mechanisms. PMID: 20201021 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
Thiopurine Therapy For IBD Improves Quality Of Life
Patients with inflammatory bowel diseases (IBDs) such as Crohn's disease or ulcerative colitis do perceive a benefit from thiopurine treatment. A report in the open access journal BMC Gastroenterology has demonstrated improved health-related quality of life in 92 IBD patients. Guillermo Bastida worked with a team of researchers from La Fe Hospital, Valencia, Spain, to investigate the controversial thiopurine treatment. He said, "The efficacy of thiopurines in the scenarios in which they are prescribed, either to induce or to maintain remission in IBD, is well proven... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Thiopurine Therapy For IBD Improves Quality Of Life
Patients with inflammatory bowel diseases (IBDs) such as Crohn's disease or ulcerative colitis do perceive a benefit from thiopurine treatment. A report in the open access journal BMC Gastroenterology has demonstrated improved health-related quality of life in 92 IBD patients... (Source: Crohn's News From Medical News Today)
Liver Biopsy
Title: Liver BiopsyCategory: Procedures and TestsCreated: 12/31/1997Last Editorial Review: 3/1/2010 (Source: MedicineNet Crohn's Disease General)
Salmonella Found in Crushed Red Pepper
Title: Salmonella Found in Crushed Red PepperCategory: Health NewsCreated: 3/1/2010 11:42:00 AMLast Editorial Review: 3/1/2010 11:42:57 AM (Source: MedicineNet Crohn's Disease General)
Predicted 'Red Tide' Could Make Shellfish a Dangerous Dish
Title: Predicted 'Red Tide' Could Make Shellfish a Dangerous DishCategory: Health NewsCreated: 2/26/2010 4:10:00 PMLast Editorial Review: 3/1/2010 (Source: MedicineNet Crohn's Disease General)
Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to infliximab
Immune therapies may act in inflammatory bowel diseases (IBD) by modulating regulatory T cells (Tregs). Therefore, we investigated the effect of infliximab (IFX) therapy on Forkhead box protein3 (Foxp3) T cells in blood and intestinal mucosa from Crohn's disease (CD) and ulcerative colitis (UC).Forty patients with active IBD (23 CD / 17 UC) were treated with IFX 5 mg/kg intravenously at weeks 0, 2, 6, and each 8 weeks thereafter. Blood samples were obtained before every infusion and T-lymphocyte subsets were characterized by flow cytometry. Foxp3 expression in intestinal biopsies from 43 patients with active IBD (19 CD / 24 UC) before and after IFX infusion and from 6 controls were assessed by quantitative reverse-transcription polymerase chain reaction and immunohistochemistry. Plasma C-r...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Non-length dependent small fiber neuropathy. A prospective case series
We report the features of non-length dependent small fiber neuropathy (SFN) and compare them to those with distal length-dependent SFN. In a series of 224 consecutive neuropathy patients, we evaluated 44 patients with SFN diagnosed in the presence of both symptoms and signs. Eleven were classified as non-length dependent SFN. Disease associations were Sjögren's syndrome (two patients), impaired glucose tolerance, rheumatoid arthritis, hepatitis C virus, Crohn's disease, and idiopathic (five patients). In the 33 patients with distal SFN, the age of onset was significantly older and more had impaired glucose metabolism (16/33). In both groups, pain was mainly characterized as burning, but patients with non-length dependent SFN more often reported an "itchy" quality and allodynia to light to...
Endoscopic-Bioptic Diagnostics, Surveillance of and Therapy for Gastrointestinal Diseases According to Guidelines.
Authors: Warich-Eitel S, Fischbach W, Eck M The present review summarises the detailed recommendations for an optimal endoscopic-bioptic diagnostic procedure, endoscopic surveillance of and therapy for gastrointestinal diseases. The recommendations are mainly based on the S 3-guidelines and have been developed by histopathologists and gastroenterologists in interdisciplinary work. The material has been arranged according to topographic regions of the gastrointestinal tract and clinical problems. The focus is placed on diagnostic and surveillance of Barrett's oesophagus, therapy and postoperative treatment for early gastrointestinal carcinoma, management of colon polyps and endoscopic surveillance of inflammatory bowel disease. Treatment recommendations for both ulcerative colitis and C...
Metastatic Crohn's disease without intestinal clinical manifestation
Os autores relatam caso de paciente feminina de 47 anos, com lesões cutâneas ulceradas, disseminadas, iniciadas sete anos antes do acompanhamento. Os achados histopatológicos de tais lesões, somados aos endoscópicos, permitiram o diagnóstico de uma entidade rara: a doença de Crohn metastática. O valor deste diagnóstico é ainda maior, por não se encontrar na literatura, relato de caso com atividade da doença de Crohn restrita às lesões cutâneas, sem a observação de queixas digestivas expressivas.The authors report the case of a 47-year-old female patient with dispersed ulcerated skin lesions that appeared 7 years before medical follow-up. Histopathological and endoscopic findings of such lesions led to the diagnosis of a rare disorder: metastatic Crohn?s disease. This dia...
Association of the interleukin-23 receptor gene variant rs11209026 with Crohn's disease in German children
Conclusion: Our study provides additional support for the strong protection of the rs11209026 (p.Arg381Gln) variant against paediatric CD. IL23R was expressed in both CD and UC with a great variability. However, expression levels showed no significant association with the disease. (Source: Acta Paediatrica)
Increased thrombin generation in inflammatory bowel diseases
Abstract: Background: Inflammatory bowel diseases (IBD) are characterized by an increased thrombotic risk of uncertain etiology. Endogenous thrombin potential (ETP), a parameter of the thrombin generation curve, represents a new tool in the evaluation of thrombotic and bleeding disorders.Aims: To study ETP in IBD patients and to correlate the results with clinical and biochemical features.Methods: Seventy-four IBD patients (37 ulcerative colitis and 37 Crohn's disease) and 74 sex- and age-matched healthy individuals. ETP was measured upon activation of coagulation with small amounts of tissue factor and phospholipids in the presence or absence of thrombomodulin; results were expressed as nM thrombin·minutes.Results: Mean±SD ETP values were significantly higher in patients (1,499±454) th...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Incidental findings frequent with MRI for Crohn's disease
Magnetic resonance imaging enterography in patients with known or suspected Crohn's disease commonly reveals incidental findings, research shows. (Source: MedWire News - Gastroenterology)
Relapsing tubulointerstitial nephritis in an adolescent with inflammatory bowel disease without aminosalicylate exposure.
We describe a rare case of a 5-aminosalicylic acid (5-ASA)-na&#xEF;ve patient who developed interstitial nephritis in association with CD with no evidence of other primary glomerulopathy. A unique feature of the case being a profound systemic inflammatory response at the time of diagnosis and a relapse in nephritis 2 months after cessation of mesalazine in the absence of any macroscopic colitis. PMID: 20178728 [PubMed - in process] (Source: Clinical Nephrology)
Tularemia
Title: TularemiaCategory: Diseases and ConditionsCreated: 2/26/2010 5:26:00 PMLast Editorial Review: 2/26/2010 5:26:04 PM (Source: MedicineNet Crohn's Disease General)
Hidradenitis suppurativa responding to treatment with infliximab
A series of four cases of severe recalcitrant hidradenitis suppurativa treated with infliximab is presented. All patients had failed to respond to prior medical and surgical management. Baseline Quantiferon-TB Gold and chest radiograph were carried out before commencement of treatment. No patients had associated Crohn's disease. All patients received induction infusions of infliximab 5 mg/kg at weeks 0, 2 and 6, followed by eight weekly maintenance infusions. The total number of infusions varied between 4 and 6. Skin photography with Sartorius scoring was used to evaluate response to treatment. All patients experienced marked improvement in their disease activity, with a mean 48% improvement in Sartorius score after one infusion (week 2, P < 0.01), and 70% improvement after three infusions...
The natural history of adult Crohn's disease in population-based cohorts
This article is not available freely or via NHS Athens username and password. NHS professionals are advised to check their local library to access the fulltext of this journal. Note: This article has been included in the Specialist Collection as it is a systematic review published in a reputable journal in the field.&nbsp; It has not been appraised for quality by NHS Evidence staff. (Source: Gastroenterology and Liver Diseases Specialist Library - Inflammatory bowel disease)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Lactose Intolerance: Too Little Is Known
Title: Lactose Intolerance: Too Little Is KnownCategory: Health NewsCreated: 2/25/2010 11:28:00 AMLast Editorial Review: 2/25/2010 11:28:53 AM (Source: MedicineNet Crohn's Disease General)
Skin Tag
Title: Skin TagCategory: Diseases and ConditionsCreated: 10/28/1998 7:24:00 AMLast Editorial Review: 2/25/2010 (Source: MedicineNet Crohn's Disease General)
Herpes Simplex Infections (Cold Sores, Non-Genital)
Title: Herpes Simplex Infections (Cold Sores, Non-Genital)Category: Diseases and ConditionsCreated: 6/16/1999 7:38:00 PMLast Editorial Review: 2/25/2010 (Source: MedicineNet Crohn's Disease General)
Extended-Release Mirapex Approved for Parkinson's Disease
Title: Extended-Release Mirapex Approved for Parkinson's DiseaseCategory: Health NewsCreated: 2/24/2010 12:10:00 PMLast Editorial Review: 2/25/2010 (Source: MedicineNet Crohn's Disease General)
Is there a role for mannan-binding lectin in the diagnosis of inflammatory bowel disease?
Abstract&nbsp;&nbsp;Mannan-binding lectin (MBL) activates the lectin-complement pathway as part of the innate immune defence by binding to the surface of microorganisms. Therefore, MBL2 presents an interesting candidate gene for the inflammatory bowel diseases, ulcerative colitis (UC) and Crohn's disease (CD). In our study, we evaluated the MBL serum concentrations and genotypes for diagnostic and classification purposes of patients with CD and UC. The MBL serum concentration was analysed in 98 CD patients and in 83 UC patients. In total, 82 patients with inflammatory rheumatic disorders and 189 healthy individuals served as controls. All study subjects were genotyped for the MBL2 polymorphisms G54D, G57E and R52C and the NOD2 (CARD15) mutations R702W, G908R and L1007fsinsC. Neither t...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease
Authors: R L Roberts, R K G Topless, A J Phipps-Green, R B Gearry, M L Barclay & T R Merriman (Source: Genes and Immunity)
Advances of Endomicroscopy for Gastrointestinal Physiology and Diseases.
Authors: Goetz M, Kiesslich R Confocal endomicroscopy is a novel technique that permits in vivo microscopy of the human gastrointestinal mucosa during ongoing endoscopy, thereby providing optical virtual biopsies. Endomicroscopy has been demonstrated to reveal histologic information in a multitude of diseases in the upper and lower gastrointestinal tract in vivo. Most studies have focused on inflammation and neoplasia, such as Barrett's esophagus, gastric cancer, celiac disease, Crohn's disease and ulcerative colitis, or colorectal neoplasias. Endomicroscopy allows obtaining "smart", targeted biopsies from regions with microscopic alterations rather than having to rely on random untargeted tissue sampling. This reduces the number of biopsies while increasing the diagnostic yield. In ad...
Behavioral Health Registry For Pediatric Inflammatory Bowel Disease To Be Created With NIH Grant
The National Institutes of Health has awarded a two-year development grant to researchers with Hasbro Children's Hospital and the Bradley Hasbro Children's Research Center to better understand the role behavioral health plays in pediatric inflammatory bowel disease (IBD), a condition that causes chronic and painful inflammation in the gastrointestinal tract... (Source: Crohn's News From Medical News Today)
Impaired erythrocyte antioxidant defense in active inflammatory bowel disease: Impact of anemia and treatment
Oxidative stress contributes to the propagation and exacerbation of inflammatory bowel disease (IBD) but the status of erythrocyte antioxidant defense remains unknown.Erythrocyte activities of superoxide dismutase-1 (SOD1), catalase, and glutathione peroxidase-1 (GPx1) were determined in 174 IBD patients and 105 controls and referred to IBD activity, inflammation severity, nutritional status, systemic oxidative stress, anemia, and treatment.Catalase and GPx1 activities were decreased in active IBD, whereas SOD1 became upregulated by IBD-related oxidative stress. In Crohn's disease (CD) corticosteroids decreased SOD1 activity. SOD1 correlated indirectly with CD activity and erythrocyte sedimentation rate (ESR) and directly with transferrin. In ulcerative colitis (UC) anemia downregulated SO...
MRI enterography shows shortcomings for Crohn's disease
Although MRI enterography can diagnose important incidental findings in a minority (more) (Source: AuntMinnie.com Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Rash
Title: RashCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 2/23/2010 (Source: MedicineNet Crohn's Disease General)
Doctors Have Many Ways to Say 'No'
Title: Doctors Have Many Ways to Say 'No'Category: Health NewsCreated: 2/22/2010 4:10:00 PMLast Editorial Review: 2/23/2010 (Source: MedicineNet Crohn's Disease General)
Patients Do Better at Hospitals That Follow Stroke Guidelines
Title: Patients Do Better at Hospitals That Follow Stroke GuidelinesCategory: Health NewsCreated: 2/22/2010 4:10:00 PMLast Editorial Review: 2/23/2010 (Source: MedicineNet Crohn's Disease General)
Emergence of KPC-producing Klebsiella pneumoniae in Italy
Conclusions: This is the second report of KPC-producing isolates in Italy, but the first concerning KPC type 2 gene, and it may have important implications for controlling the transmission of microorganisms resistant to antibiotics. (Source: BioMed Central)
Efficacy of methotrexate in ulcerative colitis: Failure or promise
Low-dose methotrexate is a widely used and efficacious therapy in chronic inflammatory disorders such as psoriasis and rheumatoid arthritis. Prospective randomized controlled trials have demonstrated the efficacy of parenteral methotrexate in Crohn's disease (CD). We performed a systematic review of the efficacy of methotrexate in ulcerative colitis (UC) and discuss the results in the context of the known pharmacokinetics and adverse events of methotrexate therapy in inflammatory bowel diseases and other inflammatory conditions.We performed a systematic review of the literature in Medline, Embase, and Web of Science. All publications describing patients with UC treated with methotrexate were included.We identified 12 studies or retrospective case series and 5 meeting abstracts that met the...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Clinical utility of C-reactive protein in patients with ileal pouch anal anastomosis
Inflammatory and noninflammatory complications of ileal pouch-anal anastomosis (IPAA) are common after restorative proctocolectomy for ulcerative colitis (UC). The clinical utility of C-reactive protein (CRP) in ileal pouch disorders has not been investigated.All IPAA patients with underlying UC who had serum CRP tested within 2 weeks of pouch endoscopy were included. The correlation between the level of serum CRP and the Pouch Disease Activity Index (PDAI) scores were evaluated. Diagnostic accuracy of CRP in assessing disease activity by PDAI endoscopy subscores was evaluated.There were 83 patients (with a total 88 CRP tests), including normal pouches (n = 7), active pouchitis (n = 6), chronic pouchitis (n = 18), Crohn's disease of the pouch (n = 23), cuffitis (n = 13), irritable pouch sy...
Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases
We previously demonstrated that in inflammatory bowel disease (IBD) there is enhanced production of interleukin (IL)-21, a cytokine that activates multiple pathways that sustain mucosal inflammation. However, the phenotype of IL-21-producing cells in IBD, and the cytokine(s) they coproduce, is not known. We here characterized the cell source of IL-21 and determined which factors regulate IL-21 in the human gut.Cytokines were analyzed in CD4+ T intestinal lamina propria lymphocytes (T-LPL) isolated from IBD patients and controls by flow cytometry. Moreover, IL-21 was evaluated in mucosal T follicular cells (TFH). To assess the involvement of IL-12 and IL-23 in the production of IL-21, T-LPL were activated in the presence or absence of IL-12 or IL-23.The proportion of IL-21-producing CD4+ T-...
Leptospira interrogans icterhaemorrhagiae in a patient with Crohn's disease
No abstract. (Source: Inflammatory Bowel Diseases)
Fistula-associated anal adenocarcinoma in Crohn's disease
We present 6 patients with CD and fistula-associated anal adenocarcinoma (FAAA) and a systematic review of published series.Retrospective charts were reviewed of 6 consecutive patients with FAAA in CD treated from 1992 through 2007. All available variables of our patients and of all available published cases were included for statistical analysis.All patients treated at our institution had severe perianal CD at presentation. The average age at time of diagnosis was 45.5 years. All patients underwent abdominoperineal resection (APR) and 4 received chemoradiation. Four patients died with metastatic disease, 1 is alive with pelvic recurrence at 55 months, and 1 is alive without evidence of disease at 19 months follow-up. A total of 23 publications including 65 patients (37 female, mean age 53...
Inadvertent conception during concomitant treatment with infliximab and methotrexate in a patient with Crohn's disease: Is the game worth the candle?
No abstract. (Source: Inflammatory Bowel Diseases)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Recognition and treatment of genitourinary complications in paediatric Crohn's disease using Infliximab
We report a myriad of urological complications in five paediatric cases, our experience from a tertiary paediatric urological and gastroenterological centre. All children with urological complications had severe Crohn's disease which necessitated the use of immuno-suppressants including Infliximab. Three of four children healed and closed their fistulas after treatment, although failed to avoid future surgery, albeit for other reasons. We suggest Infliximab should be considered as a treatment option but in the absence of a common consensus, treatment be tailored to individual cases. (Source: Acta Paediatrica)
No association between myeloproliferative neoplasms and the Crohn's disease-associated STAT3 predisposition SNP rs744166.
Authors: Jones AV, Cross NC PMID: 20179083 [PubMed - as supplied by publisher] (Source: Haematologica)
Suspected Anastomotic Recurrence of Crohn Disease after Ileocolic Resection: Evaluation with CT Enteroclysis [GASTROINTESTINAL IMAGING]
CT enteroclysis yields objective, relatively specific morphologic criteria that help differentiate between recurrence and fibrostenosis at the anastomotic site after ileocolic resection for Crohn disease. (Source: Radiology)
Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches
In this study, we show that both anti-CD4+ and anti-interferon (anti-IFN) monoclonal antibodies abrogate this phenotype and reduce the expression of tumour necrosis factor (TNF) receptor 2 and the long isoform of myosin light chain kinase, thus demonstrating that immune T cells influence the epithelial functions. In turn, intraperitoneal injection of ML-7 (a myosin light chain kinase inhibitor) normalises the values of CD4+ T cells, IFN and TNF. This reciprocal cross-talk is under the control of the gut microflora as shown by the normalisation of all parameters after antibiotic treatment. Toll-like receptor 2 (TLR2) and TLR4 expression were increased in Nod2&ndash;/&ndash; mice under basal conditions and TLR2 and TLR4 agonists induced an increased transcellular permeability in Nod2+/+ mice...
Early Crohn disease: a proposed definition for use in disease-modification trials
(Source: Gut)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Sinus Infection
Title: Sinus InfectionCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 2/22/2010 (Source: MedicineNet Crohn's Disease General)
Protein Appears Key to Intestinal Balance
Title: Protein Appears Key to Intestinal BalanceCategory: Health NewsCreated: 2/19/2010 4:10:00 PMLast Editorial Review: 2/22/2010 (Source: MedicineNet Crohn's Disease General)
Co-morbidity and Age-related Prevalence of Psoriasis: Analysis of Health Insurance Data in Germany.
In conclusion, psoriasis is associated with significant co-morbidities that imply an elevated risk of severe complications. PMID: 20169297 [PubMed - in process] (Source: Acta Derm Venereol A...)
Imaging of cell trafficking in Crohn's disease
Inflammatory bowel diseases are represented by ulcerative colitis and Crohn's disease, both consisting of a chronic, uncontrolled inflammation of the intestinal mucosa of any part of the gastrointestinal tract with patchy or continuous inflammation. Ileo-colonoscopy is considered the current gold standard imaging technique for the diagnosis. However, as the majority of patients need a long-term follow-up it would be ideal to rely on a non-invasive technique with good compliance. This review focuses on nuclear medicine imaging techniques in Crohn's disease. Different scintigraphic methods of imaging cells involved in the pathogenesis are described. The radiopharmaceuticals can be divided into non-specific radiopharmaceuticals for inflammation and specific radiopharmaceuticals that directly ...
Burning Mouth Syndrome
Title: Burning Mouth SyndromeCategory: Diseases and ConditionsCreated: 2/19/2010 10:23:00 AMLast Editorial Review: 2/19/2010 10:23:58 AM (Source: MedicineNet Crohn's Disease General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Long-term outcomes following laparoscopically assisted versus open ileocolic resection for Crohn's disease
Long-term results of laparoscopically assisted versus open ileocolic resection for Crohn's disease were evaluated in a randomized trial.Sixty patients who underwent ileocolic resection between 1999 and 2003 were followed prospectively. Primary outcomes were reoperation, readmission and repeat resection rates for recurrent Crohn's disease. Secondary outcomes were quality of life (QOL), body image and cosmesis.Five patients were lost to follow-up. Median follow-up was 6·7 (interquartile range 5·7-7·9) years. Sixteen of 29 and 16 of 26 patients remained relapse free after ileocolic resection in the laparoscopic and open groups respectively (risk difference 6 (95 per cent confidence interval - 20 to 32) per cent). Resection of recurrent Crohn's disease was necessary in two of 29 versus thre...
Long-term outcomes following laparoscopically assisted versus open ileocolic resection for Crohn's disease.
CONCLUSION:: Laparoscopically assisted ileocolic resection results in better body image and cosmesis, whereas open surgery is more likely to produce incisional hernia and obstruction. Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 20175126 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)
Protein Found To Be Key In Protecting The Gut From Infection
A signaling protein that is key in orchestrating the body's overall immune response has an important localized role in fighting bacterial infection and inflammation in the intestinal tract, according to a study by UC San Diego School of Medicine investigators, published in the journal Cell Host and Microbe... (Source: Crohn's News From Medical News Today)
New Guideline Identifies Major Risk Factors In The Development Of Colorectal Cancer In Children And Adults With Inflammatory Bowel Disease
Certain patients with inflammatory bowel disease (IBD), both ulcerative colitis and Crohn's disease of the colon, have an increased risk of developing colorectal cancer compared to individuals without IBD. A number of factors contribute to the increase in risk, which necessitates an individualized and sensible approach to surveillance in patients, according to a new medical position statement and technical review published by the American Gastroenterological Association in its official journal, Gastroenterology... (Source: Health News from Medical News Today)
New Guideline Identifies Major Risk Factors In The Development Of Colorectal Cancer In Children And Adults With Inflammatory Bowel Disease
Certain patients with inflammatory bowel disease (IBD), both ulcerative colitis and Crohn's disease of the colon, have an increased risk of developing colorectal cancer compared to individuals without IBD... (Source: Crohn's News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
FDA Tightens Controls on Anemia Drugs
Title: FDA Tightens Controls on Anemia DrugsCategory: Health NewsCreated: 2/16/2010 4:10:00 PMLast Editorial Review: 2/17/2010 (Source: MedicineNet Crohn's Disease General)
Night Sweats
Title: Night SweatsCategory: Diseases and ConditionsCreated: 1/10/2006Last Editorial Review: 2/16/2010 (Source: MedicineNet Crohn's Disease General)
AGA offers new recommendations for CRC surveillance for certain patients with IBD
(American Gastroenterological Association) Certain patients with inflammatory bowel disease (IBD), both ulcerative colitis and Crohn's disease of the colon, have an increased risk of developing colorectal cancer compared to individuals without IBD. A number of factors contribute to the increase in risk, which necessitates an individualized and sensible approach to surveillance in patients, according to a new medical position statement and technical review published by the American Gastroenterological Association in its official journal, Gastroenterology. (Source: EurekAlert! - Medicine and Health)
Immunology: Gut Reactions Gone Awry
Crohn's disease is a debilitating autoinflammatory disease of the gastrointestinal tract. Genomewide association studies have demonstrated strong links between Crohn's disease and polymorphisms in genes involved in microbial recognition (NOD2) ? [Read more] (Source: Editors' Choice)
Urinary Retention
Title: Urinary RetentionCategory: Diseases and ConditionsCreated: 2/12/2010 4:02:00 PMLast Editorial Review: 2/12/2010 4:02:15 PM (Source: MedicineNet Crohn's Disease General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Secondhand Smoke
Title: Secondhand SmokeCategory: Diseases and ConditionsCreated: 2/12/2010 3:32:00 PMLast Editorial Review: 2/12/2010 3:32:18 PM (Source: MedicineNet Crohn's Disease General)
Thiopurine therapy in inflammatory bowel disease patients: Analyses of two 8-year intercept cohorts
Thiopurines have proven efficacy in long-term maintenance therapy of inflammatory bowel disease (IBD). Limited data are available with regard to factors predicting effectiveness and failure of long-term thiopurine use in IBD patients.The data in this retrospective study are based on an 8-year intercept cohort of previous or present thiopurine-using IBD patients. Both cohorts are assessed by descriptive and statistical analysis aimed at determining thiopurine effectiveness and the variables that are predictive for failure of thiopurine therapy.In all, 363 IBD patients were included (60% female), 63% with Crohn's disease and 33% with ulcerative colitis. Overall, thiopurines were continued in 145/363 (40%) and discontinued in 208/363 (57%) patients. The proportion of patients still using thio...
Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease
Patients with ulcerative colitis and Crohn's disease are at increased risk of developing intestinal cancers via mechanisms that remain incompletely understood. However, chronic inflammation and repeated events of inflammatory relapse in inflammatory bowel disease (IBD) expose these patients to a number of signals known to have tumorigenic effects including persistent activation of the nuclear factor-[kappa]B and cyclooxygenase-2/prostaglandin pathways, release of proinflammatory mediators such as tumor necrosis factor-[alpha] and interleukin-6, and enhanced local levels of reactive oxygen and nitrogen species. These inflammatory signals can contribute to carcinogenesis via 3 major processes: 1) by increasing oxidative stress, which promotes DNA mutagenesis thus contributing to tumor initia...
Preliminary evidence supporting a framework of psychological adjustment to inflammatory bowel disease
Adjustment to chronic disease is a multidimensional construct described as successful adaptation to disease-specific demands, preservation of psychological well-being, functional status, and quality of life. Inflammatory bowel disease (IBD) can be particularly challenging due to the unpredictable, relapsing and remitting course of the disease.All participants were patients being treated in an outpatient gastroenterology clinic at a university medical center. Participants completed a survey of questionnaires assessing illness perceptions, stress, emotional functioning, disease acceptance, coping, disease impact, and disease-specific and health-related quality of life. Adjustment was measured as a composite of perceived disability, psychological functioning, and disease-specific and health-r...
NOD2 status and human ileal gene expression
NOD2 single nucleotide polymorphisms have been associated with increased risk of ileal Crohn's disease (CD). This exploratory study was conducted to compare ileal mucosal gene expression in CD patients with and without NOD2 risk alleles.Ileal samples were prospectively collected from 18 nonsmoking CD patients not treated with anti-TNF-[alpha] biologics and 9 nonsmoking control patients without inflammatory bowel disease undergoing initial resection and genotyped for the 3 major NOD2 risk alleles (Arg702Trp, Gly908Arg, Leu1007fs). Microarray analysis was performed in samples from 4 NOD2R (at least 1 risk allele) CD patients, 4 NOD2NR (no risk alleles) CD patients, and 4 NOD2NR controls. Candidate genes selected by significance analysis of microarrays (SAM) were confirmed by quantitative rev...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Laparoscopic resection with transcolonic specimen extraction for ileocaecal Crohn's disease
Ileocolic resection for Crohn's disease can be performed entirely laparoscopically. However, an incision is needed for specimen extraction. This prospective observational study assessed the feasibility of endoscopic transcolonic specimen removal.Endoscopic specimen removal was attempted in a consecutive series of ten patients scheduled for laparoscopic ileocolic resection. Primary outcomes were feasibility, operating time, reoperation rate, pain scores, morphine requirement and hospital stay. To assess applicability, outcomes were compared with previous data from patients who had laparoscopically assisted operations.Transcolonic removal was successful in eight of ten patients; it was considered not feasible in two patients because the inflammatory mass was too large (7-8 cm). Median operat...
Laparoscopic resection with transcolonic specimen extraction for ileocaecal Crohn's disease.
CONCLUSION:: Transcolonic removal of the specimen in ileocolic Crohn's disease is feasible in the absence of a large inflammatory mass but infection may be a problem. It is unclear whether the technique offers benefit compared with conventional laparoscopic surgery. Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 20155789 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)
Prevalence of Joint Hypermobility and Patterns of Articular Manifestations in Patients with Inflammatory Bowel Disease
Conclusions. JH and the HMS are common in CD patients, thus articular manifestations should be carefully interpreted. This implies an involvement of collagen varieties in the pathogenesis of IBD. (Source: Gastroenterology Research and Practice)
OTC Pain Relievers and Fever Reducers
Title: OTC Pain Relievers and Fever ReducersCategory: MedicationsCreated: 9/21/1999 8:31:00 PMLast Editorial Review: 2/11/2010 (Source: MedicineNet Crohn's Disease General)
The STAT4 Gene Influences Genetic Predisposition to Ulcerative Colitis but not Crohn's Disease in the Spanish Population: A Replication Study.
Authors: Diaz-Gallo LM, Palomino-Morales RJ, G&#xF3;mez-Garc&#xED;a M, Carde&#xF1;a C, Rodrigo L, Nieto A, Alcain G, Cueto I, L&#xF3;pez-Nevot MA, Martin J PMID: 20153791 [PubMed - as supplied by publisher] (Source: Human Immunology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Chronic Fatigue Syndrome
Title: Chronic Fatigue SyndromeCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 2/10/2010 (Source: MedicineNet Crohn's Disease General)
Health Tip: Help Prevent Travelers' Diarrhea
Title: Health Tip: Help Prevent Travelers' DiarrheaCategory: Health NewsCreated: 2/10/2010 8:10:00 AMLast Editorial Review: 2/10/2010 (Source: MedicineNet Crohn's Disease General)
Pyostomatitis vegetans as an oral manifestation of Crohn's disease in a pediatric patient
No abstract. (Source: Inflammatory Bowel Diseases)
The secretome of Campylobacter&nbsp;concisus
This study has identified several factors putatively associated with disease outcome, suggesting that C. concisus is a pathogen of the gastrointestinal tract. (Source: FEBS Journal)
Bowel Disease Flare-Ups Raise Risk of Blood Clots
People with active forms of a group of conditions known as inflammatory bowel disease, or IBD, seem to be at far greater risk of developing potentially life-threatening blood clots than previously recognized, a British study released Monday indicates. Source: Reuters Health Related MedlinePlus Topics: Crohn's Disease, Deep Vein Thrombosis, Ulcerative Colitis (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Biogen 4Q Profit Grows 48 Percent On Tysabri Sales
From Associated Press (February 9, 2010) CAMBRIDGE, Mass. -- Biogen Idec Inc. said Tuesday its profit rose 48 percent in the fourth quarter due to higher sales of its drug Tysabri, a treatment for multiple sclerosis and Crohn's disease. The... (Source: Drugs.com - Pharma News)
Smoking (How to Quit Smoking)
Title: Smoking (How to Quit Smoking)Category: Diseases and ConditionsCreated: 11/17/1999 8:42:00 PMLast Editorial Review: 2/9/2010 (Source: MedicineNet Crohn's Disease General)
Overactive Bladder
Title: Overactive BladderCategory: Diseases and ConditionsCreated: 8/30/2001 8:13:00 AMLast Editorial Review: 2/9/2010 (Source: MedicineNet Crohn's Disease General)
Inflammatory Bowel Ups Risk for Blood Clots
Title: Inflammatory Bowel Ups Risk for Blood ClotsCategory: Health NewsCreated: 2/9/2010 8:10:00 AMLast Editorial Review: 2/9/2010 (Source: MedicineNet Crohn's Disease General)
Differences between Crohn's and colitis
SWANSEA, Wales, Feb. 9 (UPI) -- British researchers said they found distinct demographic profiles for Crohn's disease and colitis -- inflammatory bowel diseases. (Source: Health News - UPI.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Bacterial Invasion: Linking Autophagy and Innate Immunity.
Authors: Galluzzi L, Kepp O, Zitvogel L, Kroemer G Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity and autophagy. PMID: 20144769 [PubMed - as supplied by publisher] (Source: Current Biology)
Lessons from the inflammasome: a molecular sentry linking Candida and Crohn's disease.
Authors: Rehaume LM, Jouault T, Chamaillard M Candida albicans is a diploid fungus that colonizes the gastrointestinal tract asymptomatically in a large proportion of the human population, but can cause life-threatening conditions in immunocompromised patients. Recent immunological investigations have revealed the Nod-like receptor pyrin domain-containing protein 3 (NLRP3) to be a cytosolic surveillance mechanism against germinating Candida. These observations point to the idea of a molecular link between Candida and a spectrum of auto-inflammatory diseases. When excessive activation of NLRP3 occurs, it can confer resistance against disseminating Candida infection but might also cause NLRP3-associated periodic syndromes. Alternatively, we propose a pathophysiological model whereby a de...
Blood in Stool, Other Factors Suggest Crohn's Disease Over Intestinal Tuberculosis
Blood in stool and sigmoid colon involvement are among the features that support a diagnosis of Crohn's disease over intestinal tuberculosis, say researchers in the January 19th online issue of the American Journal of Gastroenterology. Weight loss, by contrast, predicts intestinal tuberculosis. Reuters Health Information (Source: Medscape Today Headlines)
Comparison of Conventional Abdominal CT with MR-Enterography in Patients with Active Crohn's Disease and Acute Abdominal Pain
Conclusions: In patients with known advanced CD with acute abdominal pain conventional abdominal MD-CT, which is frequently performed as an emergency imaging procedure, is sufficient for bowel wall assessment. Based on our data, additional dedicated small bowel imaging such as MRE seems not to be necessary. (Source: Academic Radiology)
Distinct Demographic Profiles Between Crohn's Disease And Ulcerative Colitis
Although inflammatory bowel disease (IBD) [comprising mainly Crohn's disease (CD) and ulcerative colitis (UC)] is thought to affect about 150 000 people in the United Kingdom, the prevalence of severe IBD is not known. Mortality following hospitalization for IBD is significant but little has been reported on long-term follow-up. A research article published on January 28, 2010 in the World Journal of Gastroenterology addresses this problem... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Distinct Demographic Profiles Between Crohn's Disease And Ulcerative Colitis
Although inflammatory bowel disease (IBD) [comprising mainly Crohn's disease (CD) and ulcerative colitis (UC)] is thought to affect about 150 000 people in the United Kingdom, the prevalence of severe IBD is not known. Mortality following hospitalization for IBD is significant but little has been reported on long-term follow-up... (Source: Crohn's News From Medical News Today)
Serotonin May Be a Key to Treat Osteoporosis
Title: Serotonin May Be a Key to Treat OsteoporosisCategory: Health NewsCreated: 2/8/2010 11:53:00 AMLast Editorial Review: 2/8/2010 11:53:01 AM (Source: MedicineNet Crohn's Disease General)
Spectators Need to Prepare for Olympic Games, Too
Title: Spectators Need to Prepare for Olympic Games, TooCategory: Health NewsCreated: 2/6/2010 8:10:00 AMLast Editorial Review: 2/8/2010 (Source: MedicineNet Crohn's Disease General)
[Treatment adherence and use of complementary and alternative medicine in patients with inflammatory bowel disease.]
Conclusions: Non-adherence and CAM use is common in patients with IBD. Special attention should be paid to explore the identified predictive factors during follow-up visits to improve adherence to therapy and improving patient-doctor relationship. PMID: 20133244 [PubMed - in process] (Source: Orvosi Hetilap)
Endoscopic findings and clinicopathologic characteristics of colonic schistosomiasis: A report of 46 cases.
CONCLUSION: Endoscopy contributes to the diagnosis of colonic schistosomiasis although it is nonspecific. A correct diagnosis of colonic schistosomiasis can be established by endoscopy in combination with its clinicopathologic characteristics. PMID: 20135720 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
The stress of my dad's divorce brought on my Crohn's disease, reveals RICK PARFITT JNR
The Status Quo star's son tells why he'll be confined to a hospital bed when his father receives his OBE this week... and why he won't be celebrating with a drink. (Source: the Mail online | Health)
Missing Genes Linked to Extreme Obesity
Title: Missing Genes Linked to Extreme ObesityCategory: Health NewsCreated: 2/5/2010 10:53:00 AMLast Editorial Review: 2/5/2010 10:53:18 AM (Source: MedicineNet Crohn's Disease General)
Tests Show Top Tuna Brands Have High Mercury Levels
Title: Tests Show Top Tuna Brands Have High Mercury LevelsCategory: Health NewsCreated: 2/4/2010 4:10:00 PMLast Editorial Review: 2/5/2010 (Source: MedicineNet Crohn's Disease General)
Distinct demographic profiles between Crohn's disease and ulcerative colitis
(World Journal of Gastroenterology) A research team from United Kingdom conducted a large study on more than 2900 people who were hospitalized with severe Crohn's disease (CD) and ulcerative colitis (UC) in Wales. They found CD and UC have distinct demographic profiles. The higher prevalence of hospitalized CD in more deprived areas may reflect higher prevalence and higher hospital dependency. (Source: EurekAlert! - Medicine and Health)
Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis.
CONCLUSION: These results do not support the hypothesis that crypt abscesses in IBD are the result of localized dysbiosis arising from persistence of living bacteria colonizing the crypts. PMID: 20128026 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Misinterpretation of NSAID-induced Colopathy as Crohn's Disease.
Authors: Stolte M, Hartmann FO Although NSAID-induced colonopathy characterised by erosions, ulcers, strictures and diaphragms has been known for quite some time, it is not infrequently misinterpreted endoscopically and histologically as Crohn's disease. This is exemplified by the present case history of a 39-year-old man with bloody diarrhoea and a stenosis in the transverse colon that was histologically interpreted as "consistent with Crohn's disease". Treatment with glucocorticoids, however, merely gave rise to adverse reactions. After surgical treatment of the stenosis, the episodes of bloody diarrhoea persisted, and endoscopy continued to reveal erosions and ulcers in the transverse colon. Changing treatment to azathioprine also failed to produce any positive response, merely caus...
Long-Term Antibiotic Treatment Effective for Crohn's Disease
Long-term treatment with clofazimine or nitroimidazoles may help control Crohn's disease, according to the authors of a systematic review and meta-analysis. Reuters Health Information (Source: Medscape Gastroenterology Headlines)
'Prewashed' Salads May Need Another Rinse
Title: 'Prewashed' Salads May Need Another RinseCategory: Health NewsCreated: 2/4/2010 10:35:00 AMLast Editorial Review: 2/4/2010 10:35:52 AM (Source: MedicineNet Crohn's Disease General)
Meta-analysis: Antibiotic therapy in Crohn's disease
Source: Clin Infect Dis Area: News Limited trial evidence suggests that long-term treatment with some antibiotics is effective in Crohn's disease, according to a systematic review and meta-analysis. &nbsp; Crohn's disease may be associated with impaired innate immunity, and a number of bacteria have been implicated in its development and persistence. As a result, there has been interest in the use of antibacterial agents in treatment. The authors of this paper note that there has not been a published comprehensive review of this topic, and thus carried out a systematic review and meta-analysis to assess the evidence for effectiveness of antimicrobials in Crohn's. &nbsp; They performed a comprehensive literature search without language restrictions for randomised placebo-controlled...
The CD40-CD40L Pathway Contributes to the Proinflammatory Function of Intestinal Epithelial Cells in Inflammatory Bowel Disease.
Authors: Borcherding F, Nitschke M, Hundorfean G, Rupp J, von Smolinski D, Bieber K, van Kooten C, Lehnert H, Fellermann K, B&#xFC;ning J In inflammatory bowel diseases (IBD), intestinal epithelial cells (IECs) are involved in the outbalanced immune responses toward luminal antigens. However, the signals responsible for this proinflammatory capacity of IECs in IBD remain unclear. The CD40/CD40L interaction activates various pathways in immune and nonimmune cells related to inflammation and was shown to be critical for the development of IBD. Here we demonstrate CD40 expression within IECs during active IBD. Endoscopically obtained biopsies taken from Crohn's disease (n = 112) and ulcerative colitis patients (n = 67) consistently showed immunofluorescence staining for CD40 in IECs of in...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Mycobacterium marinum infection complicated by anti-tumor necrosis factor therapy.
We describe sporotrichoid spread of Mycobacterium marinum in a man with Crohn's disease treated with infliximab. After starting ethambutol and rifampin and discontinuing infliximab a worsening appeared. M. marium infection may have a potential local spread and systemic dissemination in patients treated with TNF-alpha antagonists. PMID: 20133411 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)
Health Tip: Things that May Cause or Worsen GERD
Title: Health Tip: Things that May Cause or Worsen GERDCategory: Health NewsCreated: 2/3/2010 8:10:00 AMLast Editorial Review: 2/3/2010 (Source: MedicineNet Crohn's Disease General)
Suppression of LPS-induced inflammatory responses in macrophages infected with Leishmania
Conclusions: During uptake by macrophages, Leishmania evades the activation of a broad range of cytokines and chemokines. Further, in the presence of a strong inflammatory stimulus, Leishmania suppresses certain proinflammatory cytokine responses in a parasite-specific manner, however it augments the production of other proinflammatory cytokines. Our findings highlight the complexity of inflammatory cytokine signalling regulation in the context of the macrophage and Leishmania interaction and confirm the utility of the Leishmania/ macrophage infection model as an experimental system for further studies of inflammatory regulation. Such studies may advance the development of therapies against inflammatory disease. (Source: Journal of Inflammation)
Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z-score
This study was designed to elucidate the contribution of parental height to the stature of children with inflammatory bowel disease (IBD), who often exhibit growth impairment. Accordingly, we compared patients' final adult heights and target heights based on measured parental heights and examined predictors of final adult height in pediatric IBD patients.We prospectively analyzed the growth of 295 patients diagnosed between ages 1 and 18 (211 Crohn's disease [CD], 84 ulcerative colitis [UC]) and their family members (283 mothers, 231 fathers, 55 siblings).Twenty-two percent had growth impairment (height for age Z-score (Source: Inflammatory Bowel Diseases)
New proteomic approaches for biomarker discovery in inflammatory bowel disease
There is an increasing interest in the discovery of new inflammatory bowel disease (IBD) biomarkers able to predict the future patterns of disease and to help in diagnosis, treatment, and prognosis. A biomarker is a substance that can be measured biologically and is associated with an increased risk of the disease. Biomarkers can be a genetic testing factor or proteins in biological samples such as serum, plasma, and cellular subpopulations. All of them should be studied to find out their utility in the management of IBD. Ulcerative colitis and Crohn's disease are relapsing and remitting chronic IBDs characterized by a global immune defect. The gold standard of their diagnosis is histological evaluation performed during endoscopic procedures. Several studies have focused on the identificat...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Treatment-associated acute myeloid leukemia in a patient with Crohn's disease on 6-mercaptopurine
No Abstract. (Source: Inflammatory Bowel Diseases)
Lewis and Sumner syndrome following infliximab treatment in Crohn's disease: A report of 2 cases
No abstract. (Source: Inflammatory Bowel Diseases)
Differential between Protein and mRNA Expression of CCR7 and SSTR5 Receptors in Crohn&#39;s Disease Patients
Crohn&#39;s disease (CD) is a multifactorial chronic inflammatory bowel disease of unknown cause. The aim of the present study was to explore if mRNA over-expression of SSTR5 and CCR7 found in CD patients could be correlated to respective protein expression. When compared to healthy donors, SSTR5 was over-expressed 417 &#x00B1; 71 times in CD peripheral blood mononuclear cells (PBMCs). Flow cytometry experiments showed no correlation between mRNA and protein expression for SSTR5 in PBMCs. In an attempt to find a reason of such a high mRNA expression, SSTR5 present on CD PBMCs were tested and found as biologically active as on healthy cells. In biopsies of CD intestinal tissue, SSTR5 was not over-expressed but CCR7, unchanged in PBMCs, was over-expressed by 10 &#x00B1; 3 times in the lamina...
ACR Appropriateness Criteria® on Crohn's Disease
This article discusses the usefulness of both traditional and newer imaging techniques in the management of Crohn's disease and its various clinical presentations. (Source: Journal of the American College of Radiology : JACR)
Urinary Tract Infections in Children
Title: Urinary Tract Infections in ChildrenCategory: Diseases and ConditionsCreated: 2/1/2010 5:57:00 PMLast Editorial Review: 2/1/2010 5:57:10 PM (Source: MedicineNet Crohn's Disease General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Optimizing the Use of Tumour Necrosis Factor Inhibitors in Crohns Disease: A Practical Approach
(Source: Drugs)
N.J. Law Allows Limited Medical Marijuana Use
New Jersey has become the 14th state in the nation to allow the medical use of marijuana, although its program will be the country's most restrictive. Outgoing Gov. Jon S. Corzine (D) signed the ?Compassionate Use Medical Marijuana Act? into law on Jan. 18, shortly before leaving office; the law will take effect in 6 months. The new law will remove legal penalties for the possession and use of marijuana for medical purposes. Under the law, the drug must be recommended by a licensed state physician for a qualifying medical condition such as cancer, HIV/AIDS, multiple sclerosis, amyotrophic lateral sclerosis, or Crohn's disease. (Source: Internal Medicine News)
Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review
Conclusions: The pooled detection, completion, and retention rates are acceptable for total procedures. OGIB is the most common indication for small-bowel CE, with a high detection rate and low retention rate. In addition, angiodysplasia is the most common finding in patients with OGIB. A relatively high retention rate is associated with definite or suspected CD and neoplasms. (Source: Gastrointestinal Endoscopy)
N.J. Law Allows Limited Medical Marijuana Use
New Jersey recently became the 14th state to allow the medical use of marijuana, though its law is the country's most restrictive. Last month, outgoing Gov. Jon S. Corzine (D) signed the ?Compassionate Use Medical Marijuana Act? (A804/S119) into law. The new law will remove legal penalties for the possession and use of marijuana for medical purposes. Under the law, the drug must be recommended by a licensed state physician for a qualifying medical condition such as cancer, HIV/AIDS, multiple sclerosis, amyotrophic lateral sclerosis, or Crohn's disease. (Source: Family Practice News)
Coeliac disease and bowel disease: Business association or casual meeting?
Coeliac disease (CD) is a permanent intolerance to ingested gluten in genetically predisposed individuals presenting HLA DQ2 or DQ8 haplotype, with a prevalence of 1 to 100?200 individuals. The pathophysiological grounds of CD are thought to be of autoimmune origin, and there is ample evidence showing a strong relationship with other autoimmune disorders such as diabetes mellitus type 1, autoimmune thyroiditis and other conditions . Moreover, in recent years case reports and case series have suggested the possibility of an association between CD and inflammatory bowel diseases (IBDs) . In this issue of Digestive and Liver Disease Casella et al. assessed the prevalence of CD in a large series of Italian patients with IBD, and found a low (0.5%) result, lower than in the general population...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
New Jersey Law Allows Medical Marijuana Use
New Jersey has become the 14th state to allow the medical use of marijuana, though its law is the country's most restrictive. On Jan. 18, outgoing Gov. Jon S. Corzine (D) signed the ?Compassionate Use Medical Marijuana Act? (A804/S119) into law. The new law will remove legal penalties for the possession and use of marijuana for medical purposes. Under the law, the drug must be recommended by a licensed state physician for a qualifying medical condition such as cancer, HIV/AIDS, multiple sclerosis, amyotrophic lateral sclerosis, or Crohn's disease. (Source: Rheumatology News)
Oedema and Crohn's disease.
Authors: Heidt J, van der Werf SD, Ooms EC, Groeneveld JH No abstract available. PMID: 20167965 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine)
[Baker Rosenbach erysipeloid appearing as a granulomatous cheilitis.]
CONCLUSION: Diagnosis of E. rhusiopathiae infection was confirmed by bacteriology. However, the hypothesis concerning the pathogenesis of its chronic course in our patient remains a subject of discussion. PMID: 20171435 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
New Jersey Law Allows Limited Use of Medical Marijuana
New Jersey recently became the 14th state in the nation to allow the medical use of marijuana, though its law is the country's most restrictive. Outgoing Gov. Jon S. Corzine (D) signed the ?Compassionate Use Medical Marijuana Act? (A804/S119) into law on Jan. 18, soon before leaving office. The new law will remove legal penalties for the possession and use of marijuana for medical purposes. Under the law, the drug must be recommended by a licensed state physician for a qualifying medical condition such as cancer, HIV/AIDS, multiple sclerosis (MS), amyotrophic lateral sclerosis, or Crohn's disease. (Source: Clinical Neurology News)
Metastatic Crohn Disease in a Spinal Cord Injury Patient Without Gastrointestinal Manifestation
A case is presented of cutaneous metastatic Crohn disease (CD) manifesting in a spinal cord injury (SCI) patient as multiple perianal, perigenital, and periostomal cutaneous ulcerations and a chronic anocutaneous fistula without any gastrointestinal (GI) involvement. (Source: PM&R)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Acute motor and sensory axonal neuropathy and concomitant encephalopathy during tumor necrosis factor-alpha antagonist therapy
Abstract: A woman with Crohn's disease developed acute neuropathy and concomitant encephalopathy while being treated with infliximab. The etiological investigations were negative. Infliximab was stopped and she was given four series of polyvalent immunoglobulin injections. Eighteen months later, the encephalitic symptoms had disappeared and the neuropathic symptoms were less severe. TNF-alpha antagonists have been previously blamed for triggering neurological disorders, but no cases of acute neuropathy concomitant with encephalopathy have been reported so far. (Source: Journal of the Neurological Sciences)
Early Crohn disease: a proposed definition for use in disease-modification trials
(Source: NHS Evidence - Gastroenterology and liver diseases - News)
Anorectal Crohn's Disease.
Authors: Lewis RT, Maron DJ Crohn's disease manifests with perianal or rectal symptoms in approximately one-third of patients, and is associated with a more aggressive natural history. Due to the chronic relapsing nature of the disease, surgery has been traditionally avoided. However, combined medical and surgical intervention when treating perianal fistulae has been shown to offer the best chance for success. Endoanal ultrasound examination or pelvic magnetic resonance imaging should be done in conjunction with an examination under anesthesia to characterize the disease. Any abscess should be drained and setons placed if there is active rectal inflammation or complex fistulae. Antibiotics and immunosuppressive therapy (especially with infliximab) should also be initiated. Simple fistu...
Vitamin D may fight Crohn's disease
MONTREAL, Jan. 30 (UPI) -- Canadian researchers say vitamin D can counter the effects of Crohn's disease. (Source: Health News - UPI.com)
Interstitial cells of Cajal, macrophages and mast cells in the gut musculature: morphology, distribution, spatial and possible functional interactions.
Authors: Mikkelsen HB Summary Interstitial cells of Cajal (ICC) are recognized as pacemaker cells for gastrointestinal movement and are hypothesized to be mediators of neuromuscular transmission. Intestinal motility disturbances are often associated with a reduced number of ICC and/or ultrastructural damage, sometimes associated with immune cells. Macrophages and mast cells in the intestinal muscularis externa of rodents can be found in close spatial contact with ICC. Macrophages are a constant and regularly distributed cell population in the serosa and at the level of Auerbach's plexus (AP). In human colon, ICC are in close contact with macrophages at the level of AP; suggesting functional interaction. It has therefore been proposed that ICC and macrophages interact. Macrophages and m...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Sufferers Of Crohn's Disease May Benefit From Vitamin D Supplements
A new study has found that Vitamin D, readily available in supplements or cod liver oil, can counter the effects of Crohn's disease. John White, an endocrinologist at the Research Institute of the McGill University Health Centre, led a team of scientists from McGill University and the Université de Montréal who present their findings about the inflammatory bowel disease in the latest Journal of Biological Chemistry. "Our data suggests, for the first time, that Vitamin D deficiency can contribute to Crohn's disease," says Dr... (Source: Health News from Medical News Today)
Sufferers Of Crohn's Disease May Benefit From Vitamin D Supplements
A new study has found that Vitamin D, readily available in supplements or cod liver oil, can counter the effects of Crohn's disease... (Source: Crohn's News From Medical News Today)
Can Symptoms Predict Ovarian Cancer?
Title: Can Symptoms Predict Ovarian Cancer?Category: Health NewsCreated: 1/29/2010 10:41:00 AMLast Editorial Review: 1/29/2010 10:41:52 AM (Source: MedicineNet Crohn's Disease General)
Liver Disease
Title: Liver DiseaseCategory: Diseases and ConditionsCreated: 1/14/2010 2:49:00 PMLast Editorial Review: 1/29/2010 (Source: MedicineNet Crohn's Disease General)


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